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Balasubramanian, J.
- A Robust Clinical Information on King of Carotenoids: a Systematic Review of the Literature
Abstract Views :572 |
PDF Views:437
Authors
J. Balasubramanian
1,
N. Narayanan
2,
K. Shahul Hammed Maraicar
2,
M. Murugan
2,
K. Azhagesh Raj
2,
M. Aruna
2
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095,Tamilnadu, IN
2 Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, IN
1 Shield Health Care Pvt Ltd, Chennai-600095,Tamilnadu, IN
2 Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, IN
Source
Indian Journal of Drugs and Diseases, Vol 1, No 1 (2012), Pagination: 18-25Abstract
Astaxanthin is a red carotenoid pigment extensively found in living organisms. Though Astaxanthin is a carotenoid compound, unlike β-carotene (a vitamin A precursor), cannot be converted to vitamin A. Astaxanthin, a potent antioxidant,with other biological effects protects cell membranes from harmful damage in the body. Studies suggest Astaxanthin may be effective in treating diseases, including cardiovascular, immune disorders, tumor, diabetes, neurodegenerative conditions and inflammatory conditions. Recent studies on Astaxanthin have shown enhancing immune response and decreasing DNA damage in humans. Astaxanthin is capable of crossing the blood-brain barrier in mammals.Keywords
Astaxanthin, Antioxidant, Immune ResponseFull Text
References
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- Fassett RG, Coombes JS (2009) Astaxanthin, Oxidative stress, inflammation and cardiovascular disease. Future Cardiol. 5(4), 333-342.
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- Nagaki et al., (2006) The supplementation effect of Astaxanthin on accommodative and asthennopia. J. Clin.Therap.Me.22(1),41-54.
- Nagaki Y et al., (2002) Effects of Astaxanthin on accommodation, critical flicker fusions, and pattern evoked potential in visual disply terminal workers. J.Trad. Med. 19(5), 170-173.
- Naguib YM (2000) Antioxidant activities of Astaxanthin and related carotenoids. J. Agric. Food Chem. 48(4),1150-1154.
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- Ohgami et al.(2003) Effects of Astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest. Opthal. Vis. Sci.44 (6), 2694-2701.
- Sawaki K et al. (2002) Sports performance benefits from taking natural Astaxanthin characterized by visual activity and muscle fatigue improvements in humans. J. Clin. Ther. Med. 18(9), 73-88.
- Shiratori et al. (2005) Effect of Astaxanthin on accommodation and asthenopia- Efficancy identification study in healthy volunteers. J.Clin.Therap.Med. 21 (5), 543- 556.
- Suzuki et al., (2006) Suppressive effects of Astaxanthin against rat endotoxin –induced uveitis by inhibiting the NF-kB signalling pathway.Exp.Eye Res.82,275-281.
- Takahashi and Kajita(2005) Effects of Astaxanthin on accommodative recovery. J.Clin.Therap. Med. 21(4),431-436.
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- Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H and Tada N (2009). Administration of natural Astaxanthin increases serum HDL-cholesterol and (2):520-523. Epub 2009 Oct 14.
- Formulation and in-vitro Drug Release for β-cyclodextrin Nanosphears using Emulsification Solvent-evaporation Method
Abstract Views :377 |
PDF Views:82
Authors
J. Balasubramanian
1,
N. Narayanan
1,
N. Shahul Hammed
1,
K. Maraicar
1,
N. Vijaya Kumar
1,
K. Azhagesh Raj
1
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 64-67Abstract
This study gives information about the formulation of β-cylcodextrin nanosphere by emulsification solvent-evaporation method based on emulsifying an organic phase containing the β-cylcodextrin in an aqueous phase of pluronic-F68 as surfactant. The nanospheres are loaded with hydrophobic drug and the in-vitro drug release study was conducted. The formulation of colloidal particle was associated with amphiphilic properties of the β-cylcodextrin derivatives. However, the partitioning of the β- cyclodextrin between the organic and aqueous phases is always depends on the concentration of the surfactant. In the case of nanospheres loaded with Irinotican hydrochloride, the partitioning of the drug occurs between the dispersed phase containing β- cylcodextrin and the continuous aqueous phase containing pluronic-F68.Keywords
Amphiphilic Cyclodextrins, Emulsification, Solvent-evaporation Method, Nanospheres, Irinotecan, Surfactant, Pluronic-F68Full Text
References
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- Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium
Abstract Views :456 |
PDF Views:72
Authors
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 68-73Abstract
Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.Keywords
Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro ReleaseFull Text
References
- Agarwal SP, Alka Ahuja and Khanna R (1998) Mucoadhesive buccal drug delivery; A potential alternative to conventional therapy. J.Controlled Release, 1-11.
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- Alka Ahuja, Khar RK and Javed Ali (1997) Mucoadhesive drug delivery system, Drug Development and Industrial Pharmacy. J.Controlled Release, 489-515.
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- Saisivam S (2000) Design and Evaluation of Diltiazem Hydrochloride Buccal Patches. J.Controlled Release, 62, 236-238.
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- A Preclinical Evaluation on Antioxidant and Gastroprotective Effect of Dioscorea Bulbifera in Wistar Rats
Abstract Views :559 |
PDF Views:67
Authors
Affiliations
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 3 (2012), Pagination: 149-154Abstract
The present study was undertaken to evaluate the gastro-protective effect of hydro alcohol extract of Dioscorea bulbifera (DB) tubers Linn in indomethacin-induced gastric ulcers in rats at doses of 100, 200 and 400 mg/kg body weight. The gastric lesions were significantly reduced by all doses of DB as compared with the Indomethacin (100 mg/kg body weight) treated group. In the stomach tissues of treated animals, the in-vitro antioxidant levels were evaluated. The administration of indomethacin caused a significant decrease in the levels of peroxidase, catalase (CAT) and an increase in glutathione peroxidase (GPx) and reduced glutathione (GSH), and lipid peroxidation (LPO) level. The administration of all doses of DB reversed the trend, inducing a significant increase of peroxidase, Catalase and a reduction in GPx, GSH and LPO level in tissues. These results suggest that the gastro-protective effect of DB can be attributed to its reducing effect on the oxidative damage in rats.Keywords
Gastro-protective Activity, Dioscorea Bulbifera, Indomethacin, Antioxidant ActivityFull Text
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- DHEA: The Remedy for Andropause
Abstract Views :554 |
PDF Views:391
Authors
J. Balasubramanian
1,
K. Shahul Hammed Maraicar
1,
D. Babu Ananth
1,
N. Vijayakumar
1,
R. Dhanalakishmi
1
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, Tamilnadu, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, Tamilnadu, IN
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 2 (2012), Pagination: 29-31Abstract
Andropause is a clinical and biochemical syndrome associated with advancing age in males and mainly characterized by a deficiency in serum (blood) androgen, mostly testosterone, levels. The condition is sometimes referred to as Androgen Decline in the Aging Male (ADAM), Partial Androgen Deficiency in the Aging Male (PADAM) or Aging Associated Androgen Deficiency (AAAD). Although the term andropause is used most often in the scientific literature, it is actually something of a misnomer because androgen releases never fully stops or "pauses" in the majority of aging men. A growing body of research suggests that DHEA can prevent or reverse the diseases that anti-aging experts have identified as the most prominent markers of accelerated aging: atherosclerosis (hardening and clogging o f the arteries), cancer, diabetes, and reduced immunity.Keywords
Androgen Decline, Aging Associated Decline, Aging Associated Androgen DeficiencyFull Text
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- Assessing Overweight/Obesity Using Various Tools in School Going Children of Pondicherry
Abstract Views :236 |
PDF Views:0
Authors
Affiliations
1 Department of Biochemistry, Pondicherry - 607402, IN
2 Community Medicine, Pondicherry - 607402, IN
3 Paediatrics Aarupadai Veedu Medical College and Hospital, Pondicherry - 607402, IN
1 Department of Biochemistry, Pondicherry - 607402, IN
2 Community Medicine, Pondicherry - 607402, IN
3 Paediatrics Aarupadai Veedu Medical College and Hospital, Pondicherry - 607402, IN
